
Matt Groening, known to audiences as the creator of the Simpsons and Futurama, is retiring his print comic, Life in Hell, after 34 years, with the above strip (his 1,669th in the series). As reported here, the strip led to his animation blockbusters:
“Life in Hell” actually earned Groening his big break in Hollywood. It started running in Wet Magazine in 1978, then moved to the now-defunct LA Reader, where Groening worked. The strip eventually made its way to LA Weekly. Its popularity grew, amassing a client list of more than 250 papers, when producer Polly Platt noticed “Life in Hell” and showed it to actor/producer James L. Brooks.
Brooks contacted Groening and wanted him to develop a series of “bumpers” based on “Life in Hell” for “The Tracey Ullman Show.” Groening was a bit apprehensive at the thought of handing over the rights to his characters, so he created the Simpsons to fill the slot.
Slate has a collection of tributes from cartoonists such as Alison Bechdel, Sammy Harkham, Tom Tomorrow, and R. Sikoryak (see below).

To explore Groening’s work further:

Work is hell : a cartoon book / by Matt Groening – PN6727.G76 A4 1986

School is hell : a cartoon book / by Matt Groening – PN6728.L49 G73 1987

Matt Groening’s cartooning with the Simpsons – NC1766.U53 S55 1993

The Simpsons – V-AN G734 Sim1 DVD

Futurama. Volume one created by Matt Groening – V-AN G734 Fut DVD